Occurrence of splenic leiomyosarcoma in dog: anatomopathological findings

Autores

  • Thaís de Almeida Moreira Universidade Federal Rural de Pernambuco
  • Marcelo Coelho Lopes Departamento de Patologia Animal, Universidade de Uberaba (UNIUBE), Uberaba-MG, Brasil.
  • Leilane Sousa Santos Universidade Federal de Uberlândia (UFU), Uberlândia-MG, Brasil
  • Rafael Rocha de Souza Departamento de Patologia Animal, Universidade Federal de Uberlândia (UFU), Uberlândia-MG, Brasil
  • Júnior Artur dos Reis Centro Universitário de Patos de Minas (UNIPAM), Patos de Minas-MG, Brasil.
  • José Maurício da Rocha Júnior Centro Universitário de Patos de Minas (UNIPAM), Patos de Minas-MG, Brasil.
  • Márcio de Barros Bandarra

DOI:

https://doi.org/10.26605/medvet-n3-1794

Palavras-chave:

canine, spleen, neoplasm, histochemical.

Resumo

Leiomyosarcoma is a malignant neoplasm with origin in smooth muscles. It can originate in the vessel wall and interstitium of the spleen smooth muscle, which is considered rare. The objective of this study was to describe clinical and anatomopathological findings of a splenic leiomyosarcoma in an eight-year-old bitch of the Fila breed. This splenic leiomyosarcoma weighed 9.2 kg, and had 30×27×14 cm in dimension, rounded shape, irregular outline, reddish color alternating with pale areas, friable and hemorrhagic tissues, and necrotic center. After conventional histopathological examination, the suspected diagnosis (leiomyosarcoma) was confirmed by histochemical analysis using Masson's trichrome staining (which showed the reactivity of the muscle tissue) and by immunohistochemical analysis, showed positivity for smooth muscle actin, vimentin, and desmin. This study emphasizes the importance of associating histopathological evaluation with histochemical and immunohistochemical techniques for a diagnosis of this neoplasm. The occurrence of leiomyosarcoma reported here denotes the importance of considering it for a differential diagnosis in cases of splenic tumors.

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Referências

Anzai, H.; Nozawa, H.; Tanaka, J.; Yasuda, K.; Otani, K.; Nishikawa, T.; Toshiaki, T.; Kiyomatsu, T.; Hata, K.; Kawai, K.; Ushiku, T.; Ishihara, S.; Takano, T.; Fukayama, M.; Watanabe, T. Giant leiomyosarcoma of the rectum with lymph node metastasis: a case report and review of the literature. International Journal of Surgery Case Reports, 34: 27-31, 2017. Brearley, M.J; Murphy, S. Splenic tumors. In: Arlyge, D.J.; Brearley, M.J.; Turek, M.M. Decision making in small animal oncology. Iowa: Wiley-Blackwell, 2008. Cap.11, p. 211216.

Cleveland, M.J.; Casale, S. Incidence of malignancy and outcomes for dogs undergoing splenectomy for incidentally detected nonruptured splenic nodules or masses: 105 cases (2009-2013). Journal of the American Veterinary Medical Association, 248(11): 1267-1273, 2016.

Comazzi, S.; MacNeill, A.L. Cytology of lymphoid tissues. In: Barger, A.M.; MacNeill, A.L. Small animal cytologic diagnosis. Boca Raton: CRC Press, 2017. Cap.8, p. 209-210.

Daudia, A.T.; Walker, S.; Morgan, B.; Lloyd, D.M. Leiomyosarcoma of the spleen. Surgery, 130, n.5, p.893-894, 2001.

Fossum, T.W.; Caplan, E.R. Cirurgias do sistema hemolinfático. In: Fossum, T.W. Cirurgia de pequenos animais. Rio de Janeiro: Elsevier, 2015. Cap.24, p.700-704.

Kumar, S.K.; Bhadani, P.P.; Sinha, R.; Shuchismita, Kumar, K. Giant subcutaneous leiomyosarcoma at knee joint: malignant tumour at rare site. International Journal of Medical and Dental Sciences, 5(2): 12791282, 2016.

Liptak, J.M.; Forrest, L.J. Soft tissue sarcomas. In: Withrow, S.J.; Page, R.; Vail, D.M. Small animal clinical oncology. St Louis: Elsevier Saunders, 2013. Cap. 21, p. 356-380.

Morais, H.A.; Argyle, D.J.; O´Brien, R.T. Diseases of the spleen. In: Ettinger, S.J.; Feldman, E.C. Textbooks of internal veterinary medicine: diseases of the dog and the cat. St Louis: Saunders Elsevier, 2010. Cap.206, p. 810-818.

Piovanello, P.; Viola, V.; Costa, G.; Carletti, M.; Cecera, A.; Turchetta, F.; Iudicone, R.; Catalano, G.; Santucci, A.; Recchia, F.; Fiorillo, L.; Menichella, M.A.; Baiano, G. Locally advanced leiomyosarcoma of the spleen. A case report and review of the literature. World Journal of Surgical Oncology, 28(5): 135, 2007.

Morrison, W. B. Principles of cancer diagnosis. In:_____. Cancer in dogs and cats – medical and surgical management. Teton: New Media, 2002. Cap. 7, p-166-167.

Öziş, S.E.; Gülpinar, K.; Sahli, Z.; Konak, B.B.; Keskin, M.; Özdemir, S.; Ataoğlu, Ö. Recurrent renal giant leiomyosarcoma. Ulus Cerrahi Derg, 32(2): 145-148, 2014.

Park, H.; Jeong, C.; Kim, G.; Kim, H.; Do, S.; Park, H. Primary renal fibrosarcoma with local invasion into the mesenteric membrane of a mongrel dog. Korean Journal of Veterinary Research, 55(1): 65-69, 2015. Sasaki, J.; Toyoshima, M.; Okamura, Y.; Goryo, M. Omental leiomyosarcoma with unusual giant cells in a beagle dog – short communication. Acta Veterinaria Hungarica, 64(2): 222–228, 2016.

Senol, T.; Kahramanoglu, I.; Muezzinoglu, B.; Yucesoy, I. Giant leiomyosarcoma: A case report. International Journal of Surgery Case Reports, 19: 109–111, 2016.

Serin, G.; Aydogan, A.; Yaygingul, R.; Tunca, R. Uterine leiomyosarcoma in a dog: a case report. Veterinarni Medicina, 55(8): 405– 408, 2010. Sherwood, J.M.; Haynes, A.M.; Klocke, E.; Higginbotham, M.L.; Thomson, E.M.; Weng, H.; Millard, H.A.T. Occurrence and clinicopathologic features of splenic neoplasia based on body weight: 325 Dogs (2003– 2013). Journal of the American Animal Hospital Association, 52(4): 220–226, 2016.

Spangler, W.L., Culbertson, M.R., Kass, P.H. Primary mesenchymal (nonangiomatous/nomlymphomatous) neoplasms occurring in the canine spleen: anatomic classification, immunohistoche-mistry, and mitotic activity correlated with patient survival. Veterinary Pathology, 31: 37-47, 1994. Tolosa, E.M., Rodrigues, C.J.; Behmer, O.A.; Freitas-Neto, A.G. Manual de técnicas para histologia normal e patológica. 2. ed. São Paulo: Manole, 2003. 331p.

Valli, V.E.; Bienzle, D.; Meuten, D.J.; Linder, K.E. Tumors of hemolymphatic system. In: Meuten, D. J. Tumors in domestic animals. Ames: Willey Backwell, 2017. Cap. 7, p. 203321.

Zachary, J.F.; McGavin, M.D. Bases da patologia em veterinária. 5. ed. São Paulo: Elsevier, 2013, 1344p.

Yang, C.; Liao, J.; Yu, Y.; Kao, J. Case report: splenic fibrosarcoma in a campbell's hamster. Taiwan Veterinary Journal, 40(3): 145-149, 2014.

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Publicado

31-12-2017

Como Citar

Moreira, T. de A., Lopes, M. C., Santos, L. S., de Souza, R. R., dos Reis, J. A., da Rocha Júnior, J. M., & Bandarra, M. de B. (2017). Occurrence of splenic leiomyosarcoma in dog: anatomopathological findings. Medicina Veterinária, 11(3), 197–202. https://doi.org/10.26605/medvet-n3-1794

Edição

v. 11 n. 3 (2017)

Seção

Patologia Animal

Licença

A Revista de Medicina Veterinária permite que o autor retenha os direitos de publicação sem restrições, utilizando para tal a licença  Creative Commons CC BY-NC-SA 4.0.

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