Conchectomy associated with Antimonium crudum and Echinacea angustifolia to treat cutaneous leishmaniasis in guinea pigs (Cavia porcellus): case report
DOI:
https://doi.org/10.26605/medvet-v19n2-7442Keywords:
Leishmania (Mundinia) enriettii, Cavia porcellus, ear, cytology, homeopathyAbstract
Leishmaniasis, a parasitic disease caused by protozoa of the genus Leishmania, can also affect guinea pigs (Cavia porcellus). In these animals, infection occurs by Leishmania (Mundinia) enriettii, a non-zoonotic species. Despite the range of studies conducted since its first description in 1948, there are few reports of effective treatments for the species. Thus, the objective of this work was to report a case of cutaneous leishmaniasis in a Cavia porcellus using conchectomy and homeopathic medicines as therapy. The animal had an ulcerated nodular lesion in the left ear and cytological examination indicated the presence of amastigotes of Leishmania spp. The supportive treatment that is normally recommended in these situations was ineffective. Therefore, it was decided to perform conchectomy, with the use of analgesics and antibiotic therapy in the postoperative period, as well as the homeopathic Antimonium crudum 6CH and Echinacea angustifolia 6CH. The treatment demonstrated effectiveness in reducing clinical signs and there were no relapses after 8 months of the procedure, at which point the animal died suddenly, due to an unknown cause (no necropsy was performed).Downloads
References
Alves-Sobrinho, E.V. et al. Leishmania enriettii visceralises in the trachea, lungs, and spleen of Cavia porcellus. Memórias do Instituto Oswaldo Cruz, 117: 1-10, 2022.
Becvar, T. et al. Development of Leishmania (Mundinia) in guinea pigs. Parasites & Vectors, 13(181): 2-6, 2020.
Bonamin, L.V. et al. Characterization of Antimonium crudum activity using solvatochromic dyes. Homeopathy, 109(2): 79-86, 2020.
BRASIL. Ministério da Saúde. Portaria interministerial nº 1.426, de 11 de julho de 2008. Disponível em: <https://bvsms.saude.gov.br/bvs/saudelegis/gm/2008/pri1426_11_07_2008.html>. Acesso em: 07 jul. 2025.
BRASIL. Ministério da Saúde. Manual de Vigilância da Leishmaniose Tegumentar, 2017. Disponível em: <https://bvsms.saude.gov.br/bvs/publicacoes/manual_vigilancia_leishmaniose_tegumentar.pdf>. Acesso em: 30 jan. 2025.
Bryceson, A.D.M.; Brayt, R.S.; Dumonde, D.C. Experimental cutaneous Leishmaniasis. IV. Selective suppression of cell-mediated immunity during the response of guinea-pigs to infection with Leishmania enriettii. Clinical and Experimental Immunology,16(2): 189-202, 1974.
Cotran, R.S.; Kumar, V.; Collins, T. Infectious diseases. In: Cotran, R.S.; Kumar, V.; Collins, T. Robbins pathologic basis of disease. 6th ed. Philadelphia: Saunders, 1999. p.391-392.
Dalla Rosa, L. et al. Cutaneous leishmaniasis in Cavia porcellus (guinea pig): case report. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 72(3): 744-748, 2020.
Ecco, R. et al. Leishmaniose cutânea em cobaias (Cavia porcellus). Ciência Rural, 30(3): 525-528, 2000.
Kwakye-Nuako, G.; Mosore, M.; Boakye, D.; Bates, P. Description, biology, and medical significance of Leishmania (Mundinia) chancei n. sp. (Kinetoplastea: Trypanosomatidae) from Ghana and Leishmania (Mundinia) procaviensis n. sp. (Kinetoplastea: Trypanosomatidae) from Namibia. Journal of Parasitology, 109(1): 43-50, 2023.
Lange, R.R.; Schmidt, E.M.S. Rodentia – Roedores Selvagens (Capivara, cutia, paca e ouriço). In: Cubas, Z.S; Silva, J.C.R.; Dias, J.L.C. Tratado de animais selvagens: medicina veterinária. 2ª ed. São Paulo: Editora Roca Ltda, 2014. p.2169-2237.
Muller-Jakic, B. et al. In vitro inhibition of cyclooxygenase and 5-lipoxygenase by alkamides from Echinacea and Achillea species. Planta Medica, 60(1): 37–40, 1994.
Muniz, J.; Medina, H. Leishmaniose tegumentar do cobaio (Leishmania enriettii sp.). Hospital, 3: 7-25, 1948.
Paraense, W.L. The spread of Leishmania enriettii through the body of the guinea-pigs. Transactions of the Royal Society of Tropical Medicine and Hygiene, 47(6): 556-560, 1953.
Paranaíba, L.F. et al. Leishmania enriettii (Muniz & Medina, 1948): a highly diverse parasite is here to stay. PLoS Pathogens, 13(5): 1-5, 2017.
Ribeiro, C. et al. Outbreak of leishmaniasis caused by Leishmania enriettii in guinea pigs (Cavia porcellus). Pesquisa Veterinária Brasileira, 43: 1-5, 2023.
Santana, F.R. et al. Modulation of inflammation response to murine cutaneous Leishmaniasis by homeopathic medicines: Antimonium crudum 30cH. Homeopathy, 103(4): 264-274, 2014.
Steinmüller, C. et al. Polysaccharides isolated from plant cell cultures of Echinacea purpurea enhance the resistance of immunosuppressed mice against systemic infections with Candida albicans and Listeria monocytogenes. International Journal of Immunopharmacology, 15(5): 605-614, 1993.
Thomaz Soccol, V. et al. New isolation of Leishmania enriettii Muniz and Medina, 1948 in Parana state, Brazil, 50 years after the first description, and isoenzymatic polymorphism of the L. enriettii taxon. Annals of Tropical Medicine and Parasitology, 90(5): 491-495, 1996.
Thomaz Soccol, V. et al. Guinea pigs naturally infected by Leishmania enrietti: Clinical analyses, parasite isolation and identification. Brazilian Archives of Biology and Technology, 64: 1-13 2021.
Tragni, E. et al. Anti-inflammatory activity of Echinacea angustifolia fractions separated on the basis of molecular weight. Pharmacological Research Communications, 20(5): 87–90, 1988.
Vasconcelos, J.M. et al. Leishmaniose Tegumentar Americana: perfil epidemiológico, diagnóstico e tratamento. Revista Brasileira de Análises Clínicas, 50(3): 221-227, 2018.
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Copyright (c) 2025 Nadine Moretti de Lima , Kamilla Bleil do Carmo, Laura Dametto Endele, Camila Pereira de Mendonça, Rayres Soares Gracia, Tainá Luana Vieira Lopes Zuchi
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